Publications

AH Abraham Hulst · MD PhD
Publications
60 publications · updated periodically

Publications

My work sits mainly at the intersection of perioperative diabetes management and kidney protection during cardiac surgery, built up across a PhD, several years as a clinician-scientist, and now the students I supervise. Below: the two research lines the work falls into, the PhD students producing it, and a full chronological record of everything published.

Publication metrics

60Publications
49IndexedWeb of Science Core Collection
1,287CitationsWeb of Science, to date
15H-indexWeb of Science

Publications per year

21661712185193203212221238241425326

Citations per year — sqrt scale, Web of Science

116331761186519902097211082213323270242592515326

Find my work elsewhere

Full publication records and profile pages are also maintained on the following platforms.

Scopus logo Scopus ORCID logo ORCID ResearchGate logo ResearchGate Amsterdam UMC (Pure) logo Amsterdam UMC (Pure)

Research lines

Diabetes and glucose regulation

Perioperative management of GLP-1 receptor agonists, other diabetes types, glucose monitoring technology, and screening for undiagnosed diabetes before surgery.

Top 10 publications

RCT — GLP-1 for perioperative hyperglycaemia (GLOBE trial) RCT — Metformin continuation, perioperative glucose control PRINCESS trial protocol — fasting vs carbohydrate loading for insulin resistance Incretin therapy in peri-operative & intensive care (review) Long-acting GLP-1 receptor agonists, perioperative considerations Type 1 & other diabetes types — what the anaesthetist should know Update on perioperative diabetes management HbA1c screening for undiagnosed diabetes before surgery Less common diabetes types: incidence & glucose control GLOBE substudy — liraglutide & myocardial function

Perioperative kidney protection

Why cardiac surgery injures the kidney, and what — including SGLT2 inhibition — might prevent it. The core of the MERCURI programme (see Research).

Top 10 publications

RCT — SGLT2 inhibition in sepsis-associated AKI (ovine) RCT — tempol for renal medullary hypoxia in septic AKI (ovine) RCT — vasopressor choice & kidney/brain microcirculation in CPB (ovine) RCT — dapagliflozin to prevent AKI after cardiac surgery (MERCURI-2) MERCURI-2 trial protocol — SGLT2 inhibition for renoprotection Kidney disease & cardiac surgery: marker, mediator, or both? (review) Cardiac surgery-associated AKI (review) Sex differences in cardiac surgery-associated AKI (review) Risk of perioperative SGLT2 inhibitor discontinuation Ketonaemia during cardiopulmonary bypass surgery

More research lines (including perioperative outcomes more broadly) will be added here over time.

PhD students

The students I supervise or co-supervise, and what they’ve published so far.

Robert van Wilpe

Diabetes mellitus subtypes and glucose control in the perioperative setting.

Less common types of diabetes mellitus (2021) Postoperative neurocognitive function & diabetes (2022) Type 1 & other diabetes types perioperatively (2023) HbA1c screening for undiagnosed diabetes (2024) PRINCESS trial protocol (2025) Liraglutide & fat/glucose metabolism in CPB (2025)

Lars Snel

SGLT2 inhibition and kidney protection in cardiac surgery.

Ketonaemia during cardiopulmonary bypass (2024) MERCURI-2 trial protocol (2025) Empagliflozin, kidney function & glucose metabolism in AKI (2025) Cardiovascular outcomes of perioperative SGLT2i (2025) SGLT2 inhibition and CSA-AKI, pilot RCT (2025) Perioperative SGLT2i-associated ketoacidosis, systematic review (2026)

Marjella Eijmael-Oosterom

SGLT2 inhibitors, GLP-1 agonists, and cardiac surgery-associated AKI.

Risk of perioperative SGLT2i discontinuation (2024) CGM & liraglutide in cardiac surgery (2024) MERCURI-2 trial protocol (2025) Empagliflozin, kidney function & glucose metabolism in AKI (2025) Sex differences in CSA-AKI (2025) GLP-1 RAs & SGLT2i perioperatively (2025) Cardiovascular outcomes of perioperative SGLT2i (2025) Cardiac surgery-associated AKI (2025)

Ayla Stobbe

Preoperative fasting, insulin resistance, and perioperative drug management.

PRINCESS trial protocol (2025) GLP-1 RAs & SGLT2i perioperatively (2025)

Vera de Winter

Joining the kidney-protection research line.

New PhD student — publications forthcoming

Full chronology

Every publication, in order. Numbers are stable — the Research lines and PhD students sections above link into this list.

2026
  1. Dapagliflozin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial
    Oosterom-Eijmael MJP, Hulst AH, Monteiro de Oliveira NP, et al; MERCURI-2 Study Group.
    JAMA 2026
  2. A Systematic Review and Expert Evaluation of Perioperative SGLT2 Inhibitor-Associated Ketoacidosis Case Reports
    Snel LIP, Li X, Jamaludin F, Siegelaar SE, Holleman F, Vriesendorp TM, DeVries JH, Hoekstra JBL, Preckel B, van Raalte DH, Hermanides J, Hulst AH.
    Acta Anaesthesiol Scand 2026
  3. Effects of argipressin on intraoperative fluid administration in cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC): study protocol of a randomised clinical trial (HiPress Trial)
    van Zwol J, Aalbers AGJ, van den Brom CE, Hollmann MW, Hulst AH, Lameris W, Tuinman PR, Vlaar APJ, Veelo DP, Hemmes SNT.
    BMJ Open 2026Open access →
  4. Caution Before Routine Preoperative Hemoglobin A1c Testing
    Hermanides J, Hulst AH, van Zuylen ML.
    JAMA Surg 2026
2025
  1. Effects of glucagon-like peptide-1 on systemic hemodynamics, kidney function, and intrarenal oxygenation in sheep with sepsis-associated acute kidney injury
    Hulst AH, Ow CPC, May CN, Hood SG, Plummer MP, Hermanides J, van Raalte DH, Deane AM, Bellomo R, Lankadeva YR.
    Sci Rep 2025Open access →
  2. Cardiac surgery-associated acute kidney injury
    Oosterom-Eijmael MJP, Hermanns H, Lankadeva YR, Hulst AH.
    BJA Educ 2025 Open access →
  3. Kidney disease and cardiac surgery: marker, mediator, or both?
    Hulst AH, Monaco F.
    BJA Open 2025Open access →
  4. Cardiovascular Outcomes of Perioperative Sodium-Glucose Transporter 2 Inhibition in Cardiac Surgery Patients: An Open-Label Randomized Pilot Study
    Snel LIP, Oosterom-Eijmael MJP, Hulst AH, on behalf of the MERCURI-2 study group.
    Acta Anaesthesiol Scand 2025
  5. Effects of noradrenaline, vasopressin, phenylephrine or metaraminol on kidney and brain microcirculation in ovine cardiopulmonary bypass: a randomised trial
    Jufar AH, May CN, Furukawa T, Evans RG, Cochrane AD, Marino B, Raman J, McCall PR, Hulst A, Hood SG, Trask-Marino A, Bellomo R, Miles LF, Lankadeva YR.
    Anaesthesia 2025
  6. Residual gastric content and peri-operative semaglutide use assessed by gastric ultrasound
    Hulst AH, Hermanides J, van Zuylen ML.
    Anaesthesia 2025
  7. GLP1-agonisten en SGLT2-remmers: stop ze niet rond een operatie
    Stobbe AY, Oosterom-Eijmael MJP, de Galan BE, Hermanides J, Siegelaar SE, Hulst AH.
    Ned Tijdschr Geneeskd 2025
  8. Do Sex Differences Matter in Cardiac Surgery-Associated Acute Kidney Injury? — A Narrative Review
    Oosterom-Eijmael MJP, van Eeghen SA, Lankadeva YR, Hermanides J, Hulst AH, van Raalte DH.
    J Intensive Care Med 2025
  9. Effects of tempol on renal medullary tissue hypoxia in an ovine model of Gram-negative septic acute kidney injury
    Peiris R, Trask-Marino A, Jufar A, Betrie AH, Southon A, Hood SG, Bellomo R, Hulst AH, May CN, Ow CPC, Lankadeva YR.
    Exp Physiol 2025
  10. The effects of empagliflozin on kidney function and glucose metabolism in acute kidney injury
    Snel LIP, Oosterom-Eijmael MJP, Hermanides J, van Raalte DH, Hulst AH.
    J Clin Anesth 2025
  11. Preoperative liraglutide modulates control of fat and glucose metabolism during cardiopulmonary bypass surgery
    van Wilpe R, Hulst AH, Thiessen SE, DeVries JH, Preckel B, Hermanides J.
    Endocr Connect 2025Open access →
  12. Study protocol of the PRINCESS trial — PReoperative INtermittent fasting versus CarbohydratE loading to reduce inSulin resiStance versus standard of care in orthopaedic patients: a randomised controlled trial
    Stobbe AY, de Klerk ES, van Wilpe R, Kievit AJ, Choi KF, Preckel B, Hollmann MW, Hermanides J, van Stijn MFM, Hulst AH.
    BMJ Open 2025Open access →
  13. Study protocol of the multicentre, randomised, triple-blind, placebo-controlled MERCURI-2 trial: promoting effective renoprotection in cardiac surgery patients by inhibition of sodium glucose cotransporter (SGLT)-2
    Oosterom-Eijmael M, Monteiro de Oliveira NP, Hulst AH, on behalf of the MERCURI-2 study group.
    BMJ Open 2025Open access →
  14. The effects of sodium-glucose transporter 2 inhibition on cardiac surgery-associated acute kidney injury: An open-label randomized pilot study
    Snel LIP, Oosterom-Eijmael MJP, Rampanelli E, Lankadeva YR, Plummer MP, Preckel B, Hermanides J, van Raalte DH, Hulst AH.
    J Clin Anesth 2025
2024
  1. Continuous Glucose Monitoring and the Effect of Liraglutide in Cardiac Surgery Patients: A Substudy of the Randomized Controlled GLOBE Trial
    Oosterom-Eijmael MJP, Hermanides J, Hulst AH, on behalf of the GLOBE study group.
    J Cardiothorac Vasc Anesth 2024
  2. Perioperative management of long-acting glucagon-like peptide-1 (GLP-1) receptor agonists: concerns for delayed gastric emptying and pulmonary aspiration
    van Zuylen ML, Siegelaar SE, Plummer MP, Deane AM, Hermanides J, Hulst AH.
    Br J Anaesth 2024
  3. Preoperative Glycosylated Haemoglobin Screening to Identify Older Adult Patients with Undiagnosed Diabetes Mellitus — A Retrospective Cohort Study
    van Wilpe R, van Zuylen ML, Hermanides J, DeVries JH, Preckel B, Hulst AH.
    J Pers Med 2024Open access →
  4. Risk of perioperative discontinuation of SGLT2 inhibitors
    Oosterom-Eijmael MJP, Hermanides J, van Raalte DH, Hulst AH.
    Br J Anaesth 2024
  5. Ketonaemia during cardiopulmonary bypass surgery: a prospective observational study
    Snel LIP, Li X, Weber NC, Zuurbier CJ, Preckel B, van Raalte DH, Hermanides J, Hulst AH.
    Br J Anaesth 2024
  6. Effects of sodium-glucose transporter-2 inhibition on systemic hemodynamics, renal function, and intra-renal oxygenation in sepsis-associated acute kidney injury
    Hulst AH, Ow CPC, May CN, Hood SH, Plummer MP, Hermanides J, van Raalte DH, Deane AM, Bellomo R, Lankadeva YR.
    Intensive Care Med Exp 2024Open access →
  7. Update on the perioperative management of diabetes mellitus
    Polderman JAW, Hermanides J, Hulst AH.
    BJA Educ 2024Open access →
  8. Preoperative continuation of GLP-1 receptor agonists: Response
    van Zuylen ML, Hermanides J, Hulst AH.
    Br J Anaesth 2024
2023
  1. Type 1 and other types of diabetes mellitus in the perioperative period: What the anaesthetist should know
    van Wilpe R, Hulst AH, Siegelaar SE, DeVries JH, Preckel B, Hermanides J.
    J Clin Anesth 2023
2022
  1. Comparison of Postoperative Neurocognitive Function in Older Adult Patients with and without Diabetes Mellitus
    van Zuylen ML, van Wilpe R, Ten Hoope W, Willems HC, Geurtsen GJ, Hulst AH, Hollmann MW, Preckel B, DeVries JH, Hermanides J.
    Gerontology 2022
  2. Elevated cerebrospinal fluid glucose levels and diabetes mellitus are associated with activation of the neurotoxic polyol pathway
    Tigchelaar C, van Zuylen ML, Hulst AH, Preckel B, van Beek AP, Kema IP, Hermanides J, Absalom AR.
    Diabetologia 2022Open access →
2021
  1. Postoperative infection and mortality following elective surgery in the International Surgical Outcomes Study (ISOS)
    the International Surgical Outcomes Study (ISOS) group.
    Br J Surg 2021
  2. Preoperative considerations of new long-acting glucagon-like peptide-1 receptor agonists in diabetes mellitus
    Hulst AH, Polderman JAW, Siegelaar SE, van Raalte DH, DeVries JH, Preckel B, Hermanides J.
    Br J Anaesth 2021
  3. Less common types of diabetes mellitus: Incidence and glucose control in the perioperative setting
    van Wilpe R, Hulst AH, Polderman JAW, Hollmann MW, DeVries JH, Preckel B, Hermanides J.
    J Clin Anesth 2021
2020
  1. Second update for anaesthetists on clinical features of COVID-19 patients and relevant management
    Weenink RP, Preckel B, Hulst AH, Hermanides J, de Jong MD, Schlack WS, Stevens MF, Sperna Weiland NH, Hollmann MW.
    J Clin Med 2020Open access →
  2. Effects of Liraglutide on Myocardial Function After Cardiac Surgery: A Secondary Analysis of the Randomised Controlled GLOBE Trial
    Hulst AH, Visscher MJ, Hermanides J, on behalf of the GLOBE study group.
    J Clin Med 2020Open access →
  3. Update for Anaesthetists on Clinical Features of COVID-19 Patients and Relevant Management
    Preckel B, Schultz MJ, Vlaar AP, Hulst AH, Hermanides J, de Jong MD, Schlack WS, Stevens MF, Weenink RP, Hollmann MW.
    J Clin Med 2020Open access →
2019
  1. Peri-operative management of patients with diabetes mellitus in Dutch hospitals, a nation-wide survey of protocols
    Hulst AH, Hermanides J, Hollmann MW, DeVries JH, Preckel B.
    Ned Tijdschr Anesthesiol 2019
  2. Lack of consensus on the peri-operative management of patients with diabetes mellitus
    Hulst AH, Hermanides J, Hollmann MW, DeVries JH, Preckel B.
    Eur J Anaesthesiol 2019
  3. Preoperative Continuation of Oral Hypoglycemic Drugs
    Hulst AH, Preckel B, Hollmann MW, DeVries JH, Hermanides J.
    Anesth Analg 2019
  4. Prospective observational cohort study on grading the severity of postoperative complications in global surgery research
    the International Surgical Outcomes Study (ISOS) group.
    Br J Surg 2019
  5. Liraglutide for perioperative management of hyperglycaemia in cardiac surgery patients: a multicentre randomized superiority trial
    Hulst AH, Visscher MJ, Hermanides J, on behalf of the GLOBE study group.
    Diabetes Obes Metab 2019
2018
  1. Perioperative continuation of metformin does not improve glycemic control in patients with type 2 diabetes; a randomized controlled trial
    Hulst AH, Polderman JAW, Ouweneel E, Pijl AJ, Hollmann MW, DeVries JH, Preckel B, Hermanides J.
    Diabetes Obes Metab 2018
  2. In response to: Metformin for the management of peri-operative hyperglycaemia
    Hulst AH, Hermanides J, Hans DeVries J, Preckel B.
    Diabetes Obes Metab 2018
  3. Potential Benefits of Sodium-Glucose Cotransporter-2 Inhibitors in the Perioperative Period
    Hulst AH, Hermanides J, DeVries JH, Preckel B.
    Anesth Analg 2018
  4. Incretins and the anaesthetist: a systematic review
    Hulst AH, Plummer MP, DeVries JH, Deane AM, Preckel B, Hermanides J.
    Eur J Anaesthesiol 2018
  5. A study on the other kinds of diabetes mellitus in the perioperative period
    Hulst AH, Raps P, Polderman JAW, DeVries JH, Preckel B, Hermanides J.
    Eur J Anaesthesiol 2018
  6. Current perioperative management of patients with diabetes mellitus in Dutch hospitals
    Hulst AH, Hermanides J, DeVries JH, Preckel B.
    Eur J Anaesthesiol 2018
  7. Comparison of perioperative glucose regulation in patients with type 1 vs type 2 diabetes mellitus: A retrospective cross-sectional study
    Hulst AH, Polderman JAW, Kooij FO, Vittali D, Lirk P, Hollmann MW, DeVries JH, Preckel B, Hermanides J.
    Acta Anaesthesiol Scand 2018
  8. Association of preoperative anaemia with postoperative morbidity and mortality: an observational cohort study in low-, middle-, and high-income countries
    the International Surgical Outcomes Study (ISOS) group.
    Br J Anaesth 2018
  9. Acute Kidney Injury and Risk of Death After Elective Surgery: Prospective Analysis of Data From an International Cohort Study
    the International Surgical Outcomes Study (ISOS) group.
    Anesth Analg 2018
  10. Systematic review of incretin therapy during peri-operative and intensive care
    Hulst AH, Plummer MP, Hollmann MW, DeVries JH, Preckel B, Deane AM, Hermanides J.
    Crit Care 2018Open access →
  11. The surgical safety checklist and patient outcomes after surgery: a prospective observational cohort study, systematic review and meta-analysis
    the International Surgical Outcomes Study (ISOS) group.
    Br J Anaesth 2018
  12. Study protocol of the randomised placebo-controlled GLOBE trial: GLP-1 for bridging of hyperglycaemia during cardiac surgery
    Hulst AH, Visscher MJ, Hermanides J, on behalf of the GLOBE study group.
    BMJ Open 2018Open access →
2017
  1. Use of failure-to-rescue to identify international variation in postoperative care in low-, middle- and high-income countries: A 7-day cohort study of elective surgery
    the International Surgical Outcomes Study (ISOS) group.
    Br J Anaesth 2017
  2. Massive Subcutaneous Emphysema and Bilateral Tension Pneumothoraces After Supplemental Oxygen Delivery via an Airway Exchange Catheter
    Hulst AH, Avis HJ, Hollmann MW, Stevens MF.
    A&A Case Reports 2017
  3. In Response: Massive Subcutaneous Emphysema and Bilateral Tension Pneumothoraces After Supplemental Oxygen Delivery via an Airway Exchange Catheter
    Hulst AH, Avis HJ, Hollmann MW, Stevens MF.
    A A Case Rep 2017
  4. Diabetes mellitus and perioperative glucose control: not one, but two types of diabetes
    Hulst AH, Kooij FO, DeVries JH, Lirk P, Preckel B, Hermanides J.
    Eur J Anaesthesiol 2017
  5. Critical care admission following elective surgery was not associated with survival benefit: prospective analysis of data from 27 countries
    the International Surgical Outcomes Study (ISOS) group.
    Intensive Care Med 2017
  6. In-hospital clinical outcomes after upper gastrointestinal surgery: Data from an international observational study
    the International Surgical Outcomes Study (ISOS) group.
    Eur J Surg Oncol 2017
2016
  1. Perioperative pain management in hip arthroscopy; what options are there?
    Bech NH, Hulst AH, Spuijbroek JA, van Leuken LLA, Haverkamp D.
    J Hip Preserv Surg 2016Open access →
  2. Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries
    the International Surgical Outcomes Study (ISOS) group.
    Br J Anaesth 2016
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