Publications

AH Abraham Hulst · MD PhD
Publications
54 publications · updated periodically

Publications

My work sits mainly at the intersection of perioperative diabetes management and kidney protection during cardiac surgery, built up across a PhD, several years as a clinician-scientist, and now the students I supervise. Below: the two research lines the work falls into, the PhD students producing it, and a full chronological record of everything published.

Research lines

Research line

Diabetes and glucose regulation

Perioperative management of GLP-1 receptor agonists, other diabetes types, glucose monitoring technology, and screening for undiagnosed diabetes before surgery.

van Wilpe et al. — Less common types of diabetes mellitus (2021) Hulst et al. — Long-acting GLP-1 RAs in diabetes mellitus (2021) Tigchelaar et al. — CSF glucose & the polyol pathway (2022) van Zuylen et al. — Postoperative neurocognitive function & diabetes (2022) van Wilpe et al. — Type 1 & other diabetes types perioperatively (2023) van Zuylen et al. — GLP-1 RA continuation, response (2024) Polderman et al. — Update on perioperative diabetes management (2024) van Wilpe et al. — HbA1c screening for undiagnosed diabetes (2024) van Zuylen et al. — GLP-1 RA, gastric emptying & aspiration (2024) Oosterom-Eijmael et al. — CGM & liraglutide in cardiac surgery (2024) Stobbe et al. — GLP-1 RAs & SGLT2i perioperatively (2025)
Research line

Perioperative kidney protection

Why cardiac surgery injures the kidney, and what — including SGLT2 inhibition — might prevent it. The core of the MERCURI programme (see Research).

Snel et al. — Ketonaemia during cardiopulmonary bypass (2024) Oosterom-Eijmael et al. — Risk of perioperative SGLT2i discontinuation (2024) Oosterom-Eijmael et al. — MERCURI-2 trial protocol (2025) Snel et al. — Empagliflozin, kidney function & glucose metabolism in AKI (2025) Oosterom-Eijmael et al. — Sex differences in CSA-AKI (2025) Stobbe et al. — GLP-1 RAs & SGLT2i perioperatively (2025) Snel et al. — Cardiovascular outcomes of perioperative SGLT2i (2025) Hulst & Monaco — Kidney disease & cardiac surgery (2025) Oosterom-Eijmael et al. — Cardiac surgery-associated AKI (2025)

More research lines (including perioperative outcomes more broadly) will be added here over time.

PhD students

The students I supervise or co-supervise, and what they’ve published so far.

Robert van Wilpe

Diabetes mellitus subtypes and glucose control in the perioperative setting.

Less common types of diabetes mellitus (2021) Postoperative neurocognitive function & diabetes (2022) Type 1 & other diabetes types perioperatively (2023) HbA1c screening for undiagnosed diabetes (2024) PRINCESS trial protocol (2025) Liraglutide & fat/glucose metabolism in CPB (2025)

Lars Snel

SGLT2 inhibition and kidney protection in cardiac surgery.

Ketonaemia during cardiopulmonary bypass (2024) MERCURI-2 trial protocol (2025) Empagliflozin, kidney function & glucose metabolism in AKI (2025) Cardiovascular outcomes of perioperative SGLT2i (2025)

Marjella Eijmael-Oosterom

SGLT2 inhibitors, GLP-1 agonists, and cardiac surgery-associated AKI.

Risk of perioperative SGLT2i discontinuation (2024) CGM & liraglutide in cardiac surgery (2024) MERCURI-2 trial protocol (2025) Empagliflozin, kidney function & glucose metabolism in AKI (2025) Sex differences in CSA-AKI (2025) GLP-1 RAs & SGLT2i perioperatively (2025) Cardiovascular outcomes of perioperative SGLT2i (2025) Cardiac surgery-associated AKI (2025)

Ayla Stobbe

Preoperative fasting, insulin resistance, and perioperative drug management.

PRINCESS trial protocol (2025) GLP-1 RAs & SGLT2i perioperatively (2025)

Vera de Winter

Joining the kidney-protection research line.

New PhD student — publications forthcoming

Full chronology

Every publication, in order. Numbers are stable — the Research lines and PhD students sections above link into this list.

2016
  1. Pearse RM, Clavien P-A, Demartines N, et al. Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries. Br J Anaesth 2016;117:601–9.
  2. Bech NH, Hulst AH, Spuijbroek JA, van Leuken LLA, Haverkamp D. Perioperative pain management in hip arthroscopy; what options are there? J Hip Preserv Surg 2016;3:181–9.
2017
  1. Szakmany T, Ditai J, Kirov M, et al. In-hospital clinical outcomes after upper gastrointestinal surgery: Data from an international observational study. Eur J Surg Oncol 2017;43:2324–32.
  2. Kahan BC, Koulenti D, Arvaniti K, et al. Critical care admission following elective surgery was not associated with survival benefit: prospective analysis of data from 27 countries. Intensive Care Med 2017;43:971–9.
  3. Hulst AH, Kooij FO, DeVries JH, Lirk P, Preckel B, Hermanides J. Diabetes mellitus and perioperative glucose control: not one, but two types of diabetes. Eur J Anaesthesiol 2017;34:359.
  4. Hulst AH, Avis HJ, Hollmann MW, Stevens MF. In Response: Massive Subcutaneous Emphysema and Bilateral Tension Pneumothoraces After Supplemental Oxygen Delivery via an Airway Exchange Catheter. A A Case Rep 2017;9:249.
  5. Hulst AH, Avis HJ, Hollmann MW, Stevens MF. Massive Subcutaneous Emphysema and Bilateral Tension Pneumothoraces After Supplemental Oxygen Delivery via an Airway Exchange Catheter. A&A Case Reports 2017;8:26–8.
  6. Ahmad T, Bouwman RA, Grigoras I, et al. Use of failure-to-rescue to identify international variation in postoperative care in low-, middle- and high-income countries: A 7-day cohort study of elective surgery. Br J Anaesth 2017;119:258–66.
2018
  1. Hulst AH, Visscher MJ, Godfried MB, et al. Study protocol of the randomised placebo-controlled GLOBE trial: GLP-1 for bridging of hyperglycaemia during cardiac surgery. BMJ Open 2018;8:1–6.
  2. Ahmad T, Phull MK, Fowler AJ, et al. The surgical safety checklist and patient outcomes after surgery: a prospective observational cohort study, systematic review and meta-analysis. Br J Anaesth 2018;120:146–55.
  3. Hulst AH, Plummer MP, Hollmann MW, et al. Systematic review of incretin therapy during peri-operative and intensive care. Crit Care 2018;22:1–12.
  4. Chaudery H, MacDonald N, Ahmad T, et al. Acute Kidney Injury and Risk of Death After Elective Surgery: Prospective Analysis of Data From an International Cohort Study. Anesth Analg 2018.
  5. Fowler AJ, Ahmad T, Abbott TEF, et al. Association of preoperative anaemia with postoperative morbidity and mortality: an observational cohort study in low-, middle-, and high-income countries. Br J Anaesth 2018;121:1227–35.
  6. Hulst AH, Polderman JAW, Kooij FO, et al. Comparison of perioperative glucose regulation in patients with type 1 vs type 2 diabetes mellitus: A retrospective cross-sectional study. Acta Anaesthesiol Scand 2018.
  7. Hulst AH, Hermanides J, DeVries JH, Preckel B. Current perioperative management of patients with diabetes mellitus in Dutch hospitals. Eur J Anaesthesiol 2018;35:56.
  8. Hulst AH, Raps P, Polderman JAW, DeVries JH, Preckel B, Hermanides J. A study on the other kinds of diabetes mellitus in the perioperative period. Eur J Anaesthesiol 2018;35:56.
  9. Hulst AH, Plummer MP, DeVries JH, Deane AM, Preckel B, Hermanides J. Incretins and the anaesthetist: a systematic review. Eur J Anaesthesiol 2018;35:55–6.
  10. Hulst AH, Hermanides J, DeVries JH, Preckel B. Potential Benefits of Sodium-Glucose Cotransporter-2 Inhibitors in the Perioperative Period. Anesth Analg 2018;127:306–7.
  11. Hulst AH, Hermanides J, Hans DeVries J, Preckel B. In response to: Metformin for the management of peri-operative hyperglycaemia. Diabetes Obes Metab 2018;20. doi:10.1111/dom.13166
  12. Hulst AH, Polderman JAW, Ouweneel E, et al. Perioperative continuation of metformin does not improve glycemic control in patients with type 2 diabetes; a randomized controlled trial. Diabetes Obes Metab 2018;20:749–52.
2019
  1. Hulst AH, Visscher MJ, Godfried MB, et al. Liraglutide for perioperative management of hyperglycaemia in cardiac surgery patients: a multicentre randomized superiority trial. Diabetes Obes Metab 2019.
  2. International Surgical Outcome Study group. Prospective observational cohort study on grading the severity of postoperative complications in global surgery research. Br J Surg 2019;106:e73–80.
  3. Hulst AH, Preckel B, Hollmann MW, DeVries JH, Hermanides J. Preoperative Continuation of Oral Hypoglycemic Drugs. Anesth Analg 2019;36:168–9.
  4. Hulst AH, Hermanides J, Hollmann MW, DeVries JH, Preckel B. Lack of consensus on the peri-operative management of patients with diabetes mellitus. Eur J Anaesthesiol 2019;36:168–9.
2020
  1. Preckel B, Schultz MJ, Vlaar AP, et al. Update for Anaesthetists on Clinical Features of COVID-19 Patients and Relevant Management. J Clin Med 2020;9:1495.
  2. Hulst AH, Visscher MJ, Cherpanath TGV, et al. Effects of Liraglutide on Myocardial Function After Cardiac Surgery: A Secondary Analysis of the Randomised Controlled GLOBE Trial. J Clin Med 2020;9:673.
  3. Weenink RP, Preckel B, Hulst AH, et al. Second update for anaesthetists on clinical features of COVID-19 patients and relevant management. J Clin Med 2020;9:1–19.
2021
  1. van Wilpe R, Hulst AH, Polderman JAW, et al. Less common types of diabetes mellitus: Incidence and glucose control in the perioperative setting. J Clin Anesth 2021;75:110460. doi:10.1016/j.jclinane.2021.110460
  2. Hulst AH, Polderman JAW, Siegelaar SE, van Raalte DH, DeVries JH, Preckel B, Hermanides J. Preoperative considerations of new long-acting glucagon-like peptide-1 receptor agonists in diabetes mellitus. Br J Anaesth 2021;126:567–71. doi:10.1016/j.bja.2020.10.023
  3. Wan YI, Patel A, Achary C, Hewson R, Phull M, Pearse RM. Postoperative infection and mortality following elective surgery in the International Surgical Outcomes Study (ISOS). Br J Surg 2021;108:220–7.
2022
  1. Tigchelaar C, van Zuylen ML, Hulst AH, et al. Elevated cerebrospinal fluid glucose levels and diabetes mellitus are associated with activation of the neurotoxic polyol pathway. Diabetologia 2022;65:1098–107. Open access →
  2. Van Zuylen ML, Van Wilpe R, Ten Hoope W, et al. Comparison of Postoperative Neurocognitive Function in Older Adult Patients with and without Diabetes Mellitus. Gerontology 2022. doi:10.1159/000524886
2023
  1. van Wilpe R, Hulst AH, Siegelaar SE, DeVries JH, Preckel B, Hermanides J. Type 1 and other types of diabetes mellitus in the perioperative period. What the anaesthetist should know. J Clin Anesth 2023;84:111012. doi:10.1016/j.jclinane.2022.111012
2024
  1. van Zuylen ML, Hermanides J, Hulst AH. Preoperative continuation of GLP-1 receptor agonists. Response. Br J Anaesth 2024;133:882–3. doi:10.1016/j.bja.2024.06.026
  2. Polderman JAW, Hermanides J, Hulst AH. Update on the perioperative management of diabetes mellitus. BJA Educ 2024;24:261–9. Open access →
  3. Hulst AH, Ow CPC, May CN, et al. Effects of sodium-glucose transporter-2 inhibition on systemic hemodynamics, renal function, and intra-renal oxygenation in sepsis-associated acute kidney injury. Intensive Care Med Exp 2024;12. Open access →
  4. Snel LIP, Li X, Weber NC, et al. Ketonaemia during cardiopulmonary bypass surgery: a prospective observational study. Br J Anaesth 2024. doi:10.1016/j.bja.2024.05.022
  5. Oosterom-Eijmael MJP, Hermanides J, van Raalte DH, Hulst AH. Risk of perioperative discontinuation of SGLT2 inhibitors. Br J Anaesth 2024. doi:10.1016/j.bja.2024.05.004
  6. van Wilpe R, van Zuylen ML, Hermanides J, DeVries JH, Preckel B, Hulst AH. Preoperative Glycosylated Haemoglobin Screening to Identify Older Adult Patients with Undiagnosed Diabetes Mellitus — A Retrospective Cohort Study. J Pers Med 2024;14:219. Open access →
  7. van Zuylen ML, Siegelaar SE, Plummer MP, Deane AM, Hermanides J, Hulst AH. Perioperative management of long-acting glucagon-like peptide-1 (GLP-1) receptor agonists: concerns for delayed gastric emptying and pulmonary aspiration. Br J Anaesth 2024. doi:10.1016/j.bja.2024.01.001
  8. Oosterom-Eijmael MJP, Hermanides J, van Raalte DH, Kouw IWK, DeVries JH, Hulst AH. Continuous Glucose Monitoring and the Effect of Liraglutide in Cardiac Surgery Patients: A Substudy of the Randomized Controlled GLOBE Trial. J Cardiothorac Vasc Anesth 2024;38:1965–71. doi:10.1053/j.jvca.2024.06.015
2025
  1. Oosterom-Eijmael M, Monteiro De Oliveira NP, Niesten ED, et al. Study protocol of the multicentre, randomised, triple-blind, placebo-controlled MERCURI-2 trial: promoting effective renoprotection in cardiac surgery patients by inhibition of sodium glucose cotransporter (SGLT)-2. BMJ Open 2025;15:e095504. Open access →
  2. Stobbe AY, De Klerk ES, Van Wilpe R, et al. Study protocol of the PRINCESS trial — PReoperative INtermittent fasting versus CarbohydratE loading to reduce inSulin resiStance versus standard of care in orthopaedic patients: a randomised controlled trial. BMJ Open 2025;15:e087260. Open access →
  3. van Wilpe R, Hulst AH, Thiessen SE, DeVries JH, Preckel B, Hermanides J. Preoperative liraglutide modulates control of fat and glucose metabolism during cardiopulmonary bypass surgery. Endocr Connect 2025;14. Open access →
  4. Snel LIP, Oosterom-Eijmael MJP, Hermanides J, van Raalte DH, Hulst AH. The effects of empagliflozin on kidney function and glucose metabolism in acute kidney injury. J Clin Anesth 2025;104. doi:10.1016/j.jclinane.2025.111865
  5. Peiris R, Trask-Marino A, Jufar A, et al. Effects of tempol on renal medullary tissue hypoxia in an ovine model of Gram-negative septic acute kidney injury. Exp Physiol 2025. doi:10.1113/EP092396
  6. Oosterom-Eijmael MJP, van Eeghen SA, Lankadeva YR, Hermanides J, Hulst AH, van Raalte DH. Do Sex Differences Matter in Cardiac Surgery-Associated Acute Kidney Injury? — A Narrative Review. J Intensive Care Med 2025. doi:10.1177/08850666251364783
  7. Stobbe AY, Oosterom-Eijmael MJP, de Galan BE, Hermanides J, Siegelaar SE, Hulst AH. GLP1-agonisten en SGLT2-remmers: stop ze niet rond een operatie. Ned Tijdschr Geneeskd 2025;169 (Dutch, subscription).
  8. Hulst AH, Hermanides J, van Zuylen ML. Residual gastric content and peri-operative semaglutide use assessed by gastric ultrasound. Anaesthesia 2025;80:333–42. doi:10.1111/anae.16504
  9. Jufar AH, May CN, Furukawa T, et al. Effects of noradrenaline, vasopressin, phenylephrine or metaraminol on kidney and brain microcirculation in ovine cardiopulmonary bypass: a randomised trial. Anaesthesia 2025. doi:10.1111/anae.70049
  10. Snel LIP, Oosterom-Eijmael MJP, Lankadeva YR, et al. Cardiovascular Outcomes of Perioperative Sodium-Glucose Transporter 2 Inhibition in Cardiac Surgery Patients: An Open-Label Randomized Pilot Study. Acta Anaesthesiol Scand 2025;69. doi:10.1111/aas.70075
  11. Hulst AH, Monaco F. Kidney disease and cardiac surgery: marker, mediator, or both? BJA Open 2025;16:100507. Open access →
  12. Oosterom-Eijmael MJP, Hermanns H, Lankadeva YR, Hulst AH. Cardiac surgery-associated acute kidney injury. BJA Educ 2025. Open access →
2026
  1. Hermanides J, Hulst AH, van Zuylen ML. Caution Before Routine Preoperative Hemoglobin A1c Testing. JAMA Surg 2026. doi:10.1001/JAMASURG.2026.0478

Citations follow my own list of record. Where a DOI or open-access link isn’t shown, the article doesn’t have one publicly available, or is behind a journal paywall.

Research programme → For clinicians → Full ORCID record →