Perioperative glucose control & the treatment of diabetes mellitus
Glucose-lowering therapies and the optimal treatment of patients with diabetes mellitus in the perioperative period. Diabetes is one of the most common chronic conditions in the general population — it raises both the likelihood of needing surgery and the perioperative risk of complications. These high-risk patients are cared for daily by every physician working perioperatively in the Netherlands.
Collaborations
PhD students
Robert van Wilpe
Diabetes mellitus subtypes and glucose control in the perioperative setting.
Ayla Stobbe
Preoperative fasting, insulin resistance, and perioperative drug management.
Co-supervisors
Daniel H. van Raalte, Jeroen Hermanides.
Collaborators
Amsterdam UMC, anaesthesia
Benedikt Preckel, Markus W. Hollmann, Jorinde A.W. Polderman, Mark L. van Zuylen.
Amsterdam UMC, endocrinology
J. Hans DeVries, Sarah E. Siegelaar.
Patient organisations
Funding & main projects
Four linked grants and studies, from completed trial to ongoing protocol.
GLOBE
Multicentre randomised trial of liraglutide (a GLP-1 receptor agonist) for perioperative glucose control in cardiac surgery. Funded by a Novo Nordisk Investigator-Initiated Study grant.
CGM
Continuous glucose monitoring substudy of the GLOBE trial, examining liraglutide’s effect on glycaemic variability around cardiac surgery.
PRINCESS
Preoperative intermittent fasting versus carbohydrate loading to reduce insulin resistance in orthopaedic patients — a randomised controlled trial.
GUIDE
Multicentre, cluster-randomised trial testing whether a proactive basal-bolus insulin regimen — versus the standard reactive sliding-scale regimen — reduces surgical site infections after elective GI or vascular surgery in patients with type 2 diabetes. Led by Sarah Siegelaar; funded by ZonMw (Goed Gebruik Geneesmiddelen).
Read the trial page →